≥99%
170851-70-4
711.85 g/mol
Ipamorelin
Ipamorelin is a 5-amino acid synthetic peptide growth hormone secretagogue supplied for in-vitro GHS-R1a receptor-binding assays and selectivity profiling.
Minimum order: 10 units per compound, across any mix of sizes.
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Third-party tested
Supplied to qualified labs and institutional buyers. Institutional use & buyer eligibility
Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C₃₈H₄₉N₉O₅ |
| CAS Number | 170851-70-4 |
| Molar Mass | 711.85 g/mol |
| Amino Acid Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ (pentapeptide) |
| Synonyms | NNC 26-0161, Ipamorelin acetate |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and aqueous laboratory solvent |
| Organoleptic Profile | White lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 21 days |
| Composition | Lyophilized ipamorelin acetate salt |
How is Ipamorelin Used in Research?
Ipamorelin is a 5-amino acid synthetic pentapeptide growth hormone secretagogue supplied as a lyophilized reference standard for in-vitro GHS-R1a (ghrelin receptor) binding assays and selectivity profiling. The compound is characterized in laboratory workflows as a high-selectivity GHS-R1a ligand; in-vitro binding assays profile its affinity relative to broader-spectrum GHS reference compounds such as GHRP-6 and GHRP-2.
At the molecular level, ipamorelin is studied in recombinant GHS-R1a expression systems and cultured pituitary somatotroph cell lines. Binding activates phospholipase C through Gq/11-protein coupling; standard laboratory readouts include IP1/IP3 accumulation assays and intracellular calcium-flux assays. The pentapeptide's selectivity is profiled in parallel panels against cortisol, ACTH, prolactin, FSH, LH, and TSH receptor systems — making it a useful reference tool for receptor-selectivity characterization.
Researchers use ipamorelin as a reference standard in analytical method development (HPLC identity and purity assays, LC-MS mass-accuracy work) and as a GHS-R1a reference ligand for comparability testing of novel secretagogue analogs. Not for use in any living organism.
This product is supplied in a lyophilized form and requires reconstitution prior to laboratory handling. For research and laboratory use only. Not for human or veterinary consumption.
Areas of Study
In-Vitro GHS-R1a Binding Assays
Applied as a reference ligand in competitive binding and functional (IP1, calcium-flux) assays on recombinant GHS-R1a cell systems.
Receptor Selectivity Profiling
Used in multi-receptor panels to characterize selectivity versus cortisol, ACTH, prolactin, FSH, LH, and TSH receptor systems.
Analytical Method Development
Serves as an identity and purity reference standard in HPLC, LC-MS, and comparability work against novel GHS analogs.
Structural Characterization
Characterized by mass spectrometry and circular dichroism to confirm sequence identity and secondary-structure content of the pentapeptide.
Combination Receptor Studies
Used alongside GHRH-receptor reference ligands such as CJC-1295 no DAC in two-receptor in-vitro co-activation studies.
References
- [1]Raun K, Hansen BS, Johansen NL, et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552-561.
- [2]Johansen PB, Nowak J, Skjaerbaek C, et al. (1999). Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Hormone & IGF Research, 9(2), 106-113.
- [3]Anderson LL, Jeftinija S, Scanes CG, et al. (2004). Physiology of ghrelin and related peptides. Domestic Animal Endocrinology, 29(1), 111-144.
Disclaimer: The information provided is for research reference only and does not constitute medical advice. Products are sold strictly for in-vitro research use.
Certificate of Analysis (COA)
Third-Party Verified Quality
Every batch of Ipamorelin is independently tested by an A2LA-accredited (ISO 17025:2017) third-party laboratory using HPLC-UV/VIS for purity and measured quantity. Each COA carries the lab's signed report and a batch-specific lot number. We publish these results publicly so you can verify exactly what you're getting.
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