≥99%
CJC-1295 with DAC + Ipamorelin Blend
A lyophilized blend pairing CJC-1295 with DAC (extended-half-life GHRH analog) and Ipamorelin (selective GHS-R1a agonist) for in-vitro receptor co-activation studies.
1 vial × $130 each
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Third-party tested
Supplied to qualified labs and institutional buyers. Institutional use & buyer eligibility
Characteristics
| Property | Value |
|---|---|
| Components | CJC-1295 with DAC (D-Ala²-modified GHRH 1-29 + DAC linker) + Ipamorelin |
| CJC-1295 (with DAC) Molecular Formula | C₁₆₅H₂₆₉N₅₀O₄₆ |
| Ipamorelin Molecular Formula | C₃₈H₄₉N₉O₅ |
| CJC-1295 (with DAC) Molar Mass | 3647.27 g/mol |
| Ipamorelin Molar Mass | 711.85 g/mol |
| Physical Form | Lyophilized powder blend |
| Solubility | Both components soluble in aqueous laboratory solvent |
| Organoleptic Profile | White to off-white lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 21 days |
| Composition | Lyophilized blend of CJC-1295 with DAC acetate and Ipamorelin acetate |
How is CJC-1295 with DAC + Ipamorelin Blend Used in Research?
The CJC-1295 with DAC + Ipamorelin blend is a lyophilized research formulation combining a 30-amino acid GHRH analog with a Drug Affinity Complex (DAC) maleimide modification (3647.27 g/mol) and a 5-amino acid synthetic pentapeptide (711.85 g/mol) for in-vitro two-receptor co-activation studies. Distinct from the CJC-1295 no DAC variant of this blend in pharmacokinetic profile: the DAC modification covalently couples to endogenous albumin in preclinical models, extending serum half-life from minutes (no DAC) to days. Supplied as a laboratory research standard targeting GHRH-R and GHS-R1a binding assays in parallel. Not for use in any living organism.
Characterization workflows profile the blend in recombinant GHRH-R and GHS-R1a expression systems with standard biochemical readouts including cAMP accumulation (Gs-cAMP-PKA pathway) and IP1/calcium-flux panels (Gq/11-PLC-calcium pathway). The DAC component lets researchers model sustained-baseline GHRH-R activation, while Ipamorelin's pulsatile GHS-R1a activation is profiled against that baseline — a common research framing for studying convergent signaling under steady-state versus pulsed-stimulus conditions.
Researchers use this blend as a combined reference mixture for analytical method development (HPLC/LC-MS comparability assays requiring simultaneous quantitation of both peptides) and as a two-receptor co-activation reference for functional characterization of novel GHRH analogs and GHS-R1a agonists. The DAC variant is the appropriate reference for studies modeling extended-pulse-frequency GH-axis dynamics; the no-DAC variant remains the appropriate reference for short-half-life pulse-burst protocols.
This product is supplied in a lyophilized form and requires reconstitution prior to laboratory handling. For research and laboratory use only. Not for human or veterinary consumption.
Areas of Study
Sustained-Baseline + Pulsed-Stimulus Studies
DAC-extended GHRH-R activation provides a steady-state baseline against which Ipamorelin's pulsatile GHS-R1a stimulus can be profiled in two-receptor functional assays.
Two-Receptor In-Vitro Co-Activation
Applied as a combined reference mixture for parallel GHRH-R and GHS-R1a binding and functional readouts in recombinant cell systems.
Pharmacokinetic Method Development
Used as the long-half-life reference standard for HPLC and LC-MS workflows quantifying albumin-bound versus free GHRH-analog fractions in preclinical samples.
Receptor Selectivity Profiling
Applied in multi-receptor competitive-binding panels to profile each component's selectivity signature within the two-component blend.
Convergent Signaling Characterization
Profiles Gs-cAMP-PKA versus Gq/11-PLC-calcium pathway readouts simultaneously in cultured somatotroph cell lines.
References
- [1]Teichman SL, Neale A, Lawrence B, et al. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. Journal of Clinical Endocrinology & Metabolism, 91(3), 799-805.
- [2]Ionescu M, Frohman LA. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. Journal of Clinical Endocrinology & Metabolism, 91(12), 4792-4797.
- [3]Raun K, Hansen BS, Johansen NL, et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552-561.
- [4]Bowers CY, Granda R, Mohan S, et al. (2004). Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I) by a combination of the GH-releasing peptide-6 and GH-releasing hormone. Journal of Clinical Endocrinology & Metabolism, 89(10), 5174-5181.
- [5]Léger J, Reverchon M, Porquet D, et al. (2009). Long-acting CJC-1295 analog stimulates the GH-IGF-I axis in healthy and growth-deficient preclinical models. Growth Hormone & IGF Research, 19(2), 137-144.
Disclaimer: The information provided is for research reference only and does not constitute medical advice. Products are sold strictly for in-vitro research use.
Certificate of Analysis (COA)
Third-Party Verified Quality
Every batch of CJC-1295 with DAC + Ipamorelin Blend is independently tested by an A2LA-accredited (ISO 17025:2017) third-party laboratory using HPLC-UV/VIS for purity and measured quantity. Each COA carries the lab's signed report and a batch-specific lot number. We publish these results publicly so you can verify exactly what you're getting.
View Lab ResultsRelated Products
3-for-2GIP3
10mg – 30mg
Triple-agonist research peptide targeting GIP, glucagon, and incretin receptors in preclinical metabolic studies.
CJC-1295 (no DAC)
5mg – 10mg
CJC-1295 is a 30-amino acid synthetic GHRH analog with a Drug Affinity Complex modification, supplied for in-vitro receptor-binding and half-life characterization studies.
Ipamorelin
5mg – 10mg
Ipamorelin is a 5-amino acid synthetic peptide growth hormone secretagogue supplied for in-vitro GHS-R1a receptor-binding assays and selectivity profiling.
Tesamorelin
5mg – 10mg
A synthetic GHRH analog supplied as a lyophilized reference standard for in-vitro GHRH-receptor-binding assays, selectivity profiling, and analytical method development. Not for use in any living organism.
Frequently Bought Together
CJC-1295 with DAC + Ipamorelin Blend
10mg (5mg/5mg)
$130
GIP3
10mg
$100
CJC-1295 (no DAC)
5mg
$45
Bundle total
$275