≥99%
863288-34-0
3367.97 g/mol
Researchers studying CJC-1295 (no DAC) often combine
Save $15 with the CJC-1295 + Ipamorelin Blend
All 2 compounds in a single lyophilized vial. Pre-blended at researcher-validated ratios for in-vitro co-incubation studies — no separate reconstitutions to manage.
Buying singles
- CJC-1295 (no DAC) 5mg$45
- Ipamorelin 5mg$45
CJC-1295 + Ipamorelin Blend
10mg (5mg/5mg)
CJC-1295 (no DAC)
CJC-1295 is a 30-amino acid synthetic GHRH analog with a Drug Affinity Complex modification, supplied for in-vitro receptor-binding and half-life characterization studies.
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Supplied to qualified labs and institutional buyers. Institutional use & buyer eligibility
Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| CAS Number | 863288-34-0 |
| Molar Mass | 3367.97 g/mol |
| Amino Acid Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ |
| Synonyms | Modified GRF 1-29, Mod GRF (1-29), CJC-1295 without DAC, Tetrasubstituted GRF (1-29) |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in sterile water and aqueous laboratory solvent |
| Organoleptic Profile | White lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 21 days |
| Composition | Lyophilized Modified GRF (1-29) acetate salt |
How is CJC-1295 (no DAC) Used in Research?
CJC-1295 (no DAC), also known as Modified GRF (1-29) or Mod GRF (1-29), is a 30-amino acid synthetic GHRH analog supplied as a lyophilized reference standard for in-vitro GHRH-receptor binding and half-life characterization studies. Four amino acid substitutions (positions 2, 8, 15, and 27) relative to native GHRH(1-29) improve in-vitro stability against dipeptidyl peptidase-4 (DPP-4) and other protease panels used in laboratory characterization. This no-DAC form lacks the maleimidopropionic acid linker present in the Drug Affinity Complex variant.
Laboratory workflows characterize CJC-1295 no DAC as a GHRH-receptor ligand in recombinant GHRH-R expression systems and cultured somatotroph cell lines. Binding activates adenylyl cyclase through Gs-protein coupling; standard readouts include cAMP accumulation assays and PKA-substrate phosphorylation panels.
Researchers use this compound as a reference standard for in-vitro receptor-binding profiling, half-life characterization in synthetic serum stability assays, and two-receptor in-vitro co-activation studies alongside GHS-R1a reference ligands such as ipamorelin. Not for use in any living organism.
This product is supplied in a lyophilized form and requires reconstitution prior to laboratory handling. For research and laboratory use only. Not for human or veterinary consumption.
Areas of Study
In-Vitro GHRH-R Binding Assays
Used as a reference GHRH-R ligand in cAMP accumulation and competitive-binding assays on recombinant GHRH-R cell systems.
Half-Life Characterization
Profiled in synthetic serum and DPP-4 protease stability assays to characterize in-vitro degradation kinetics against parent GHRH(1-29).
Analytical Method Development
Applied as an identity, purity, and potency reference standard in HPLC and LC-MS comparability work.
Structural Analysis
Characterized by circular dichroism and mass spectrometry to confirm sequence identity and secondary-structure profile.
Two-Receptor In-Vitro Co-Activation Studies
Used alongside GHS-R1a reference ligands such as ipamorelin in cultured somatotroph cell systems for combined receptor-activation profiling.
References
- [1]Jetté L, Bhatt R, Bhatt DL, et al. (2005). hGRF1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats. Peptides, 26(5), 827-834.
- [2]Alba M, Fintini D, Bowers CY, et al. (2005). Effects of GHRH and GHRP-6, alone and in combination, on GH secretion in aged rats. Journal of Endocrinology, 185(3), 543-551.
- [3]Martin B, Lopez de Maturana R, Brenneman R, et al. (2005). Class II G protein-coupled receptors and their ligands in neuronal function and protection. NeuroMolecular Medicine, 7(1-2), 3-36.
Disclaimer: The information provided is for research reference only and does not constitute medical advice. Products are sold strictly for in-vitro research use.
Certificate of Analysis (COA)
Third-Party Verified Quality
Every batch of CJC-1295 (no DAC)is independently tested by an A2LA-accredited (ISO 17025:2017) third-party laboratory using HPLC-UV/VIS for purity and measured quantity. Each COA carries the lab's signed report and a batch-specific lot number. We publish these results publicly so you can verify exactly what you're getting.
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Frequently Bought Together
CJC-1295 (no DAC)
5mg
$45
GIP3
10mg
$100
Ipamorelin
5mg
$45
Bundle total
$190