≥99%
189691-06-3
1025.18 g/mol
PT-141
Bremelanotide. A melanocortin (MC1R/MC4R) receptor agonist supplied as a lyophilized reference standard for in-vitro receptor-binding assays and analytical characterization. Not for use in any living organism.
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Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| CAS Number | 189691-06-3 |
| Molar Mass | 1025.18 g/mol |
| Amino Acid Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (cyclic heptapeptide) |
| Synonyms | Bremelanotide, Vyleesi (brand), PT-141 |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and DMSO |
| Organoleptic Profile | White lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C |
| Composition | Lyophilized bremelanotide acetate salt |
How is PT-141 Used in Research?
PT-141, also known as bremelanotide, is a cyclic heptapeptide melanocortin receptor agonist derived from the synthetic alpha-melanocyte-stimulating hormone analog Melanotan II. Unlike phosphodiesterase inhibitors that act peripherally on vascular smooth muscle, bremelanotide acts centrally on the melanocortin system — specifically the melanocortin-4 receptor (MC4R) and melanocortin-3 receptor (MC3R) in the hypothalamus.
Mechanistically, MC4R activation in the medial preoptic area and paraventricular nucleus of the hypothalamus modulates neural circuits involved in sexual-behavior research, through downstream effects on oxytocin, dopamine, and other neurotransmitter systems. In preclinical models, bremelanotide has been characterized in sexual-behavior research models through a mechanism independent of peripheral vascular pathways.
Beyond sexual-behavior research, melanocortin receptor pharmacology is an active area of investigation with implications for energy-homeostasis research, inflammatory-marker modulation in preclinical studies, and neuroprotective assay models. MC4R plays a role in appetite regulation and energy balance research, and the melanocortin system is involved in modulation of inflammatory-marker responses through MC1R and MC3R. Preclinical research has investigated melanocortin analogs in hemorrhagic-shock, ischemia-reperfusion, and neuroinflammatory research models.
This product is supplied in a lyophilized form and requires reconstitution prior to laboratory handling. For research and laboratory use only. Not for human or veterinary consumption.
Areas of Study
Melanocortin Receptor Pharmacology
Studied as a tool compound for understanding MC3R and MC4R signaling in neural circuits controlling sexual behavior, appetite, and energy homeostasis.
Central Nervous System Mechanisms
Preclinical research explores bremelanotide's effects on hypothalamic oxytocin and dopamine release pathways underlying arousal and motivation.
Sexual Behavior Research
Investigated in preclinical models for effects on sexual behavior through central melanocortin receptor-mediated pathways independent of nitric oxide.
Inflammatory-Marker Modulation
Melanocortin receptor activation studied for modulation of inflammatory-marker responses through MC1R and MC3R in preclinical models.
Energy Homeostasis
MC4R's role in appetite regulation and energy balance makes melanocortin agonists subjects of metabolic research.
References
- [1]Hadley ME, Dorr RT. (2006). Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides, 27(4), 921-930.
- [2]Giuliano F, Rampin O, Allard J. (2002). Neurophysiology and pharmacology of female genital sexual response. Journal of Sex & Marital Therapy, 28(sup1), 101-121.
- [3]Van der Ploeg LH, Martin WJ, Howard AD, et al. (2002). A role for the melanocortin 4 receptor in sexual function. Proceedings of the National Academy of Sciences, 99(17), 11381-11386.
Disclaimer: The information provided is for research reference only and does not constitute medical advice. Products are sold strictly for in-vitro research use.
Certificate of Analysis (COA)
Third-Party Verified Quality
Every batch of PT-141is independently tested by an A2LA-accredited (ISO 17025:2017) third-party laboratory using HPLC-UV/VIS for purity and measured quantity. Each COA carries the lab's signed report and a batch-specific lot number. We publish these results publicly so you can verify exactly what you're getting.
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