≥99%
1208243-50-8
1257.34 g/mol
ARA-290
ARA-290 is an 11-amino acid synthetic peptide derived from erythropoietin supplied as a lyophilized research standard for in-vitro receptor-binding assays and structural characterization. Not for use in any living organism.
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Supplied to qualified labs and institutional buyers. Institutional use & buyer eligibility
Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C₅₁H₈₄N₁₆O₂₁ |
| CAS Number | 1208243-50-8 |
| Molar Mass | 1257.34 g/mol |
| Amino Acid Sequence | Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Synonyms | ARA-290, Cibinetide, EPO-derived tissue-protective peptide |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and physiological saline |
| Organoleptic Profile | White lyophilized powder; odorless |
| Purity | ≥97% by HPLC |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 7 days |
How is ARA-290 Used in Research?
ARA-290 is an 11-amino acid synthetic peptide derived from a structural domain of erythropoietin, supplied as a lyophilized research standard for in-vitro receptor-binding assays and structural characterization. Not for use in any living organism.
Laboratory workflows profile ARA-290 in innate-repair-receptor (IRR) binding assays. The IRR is a heterodimer of the EPO receptor (EPOR) and the beta common receptor (CD131); this receptor signature is distinct from the erythropoietic EPOR homodimer, and in-vitro binding panels are used to characterize the selectivity of the 11-amino acid fragment. Functional readouts include cytoprotection markers in preclinical cell-culture stress assays and cytokine-marker panels (TNF-alpha, IL-6) in cultured immune-cell systems.
Researchers use ARA-290 as an analytical reference standard in HPLC and LC-MS identity and purity assays, as a structural reference in mass-spectrometry and circular-dichroism characterization, and as an IRR-selective reference ligand for comparability testing of novel EPO-derived peptide fragments.
This product is supplied in a lyophilized form and requires reconstitution prior to laboratory handling. For research and laboratory use only. Not for human or veterinary consumption.
Areas of Study
In-Vitro Receptor-Binding Assays
Used as a reference ligand in EPOR/CD131 heterodimer binding panels and EPOR homodimer selectivity controls.
Structural Characterization
Characterized by mass spectrometry and circular dichroism to confirm sequence identity and secondary-structure content of the 11-amino acid peptide.
Analytical Method Development
Applied as an identity and purity reference standard in HPLC and LC-MS comparability work.
Cytokine-Marker Panels
Profiled in cultured immune-cell systems for TNF-alpha and IL-6 marker readouts under standardized in-vitro stress conditions.
Cell-Culture Cytoprotection Assays
Used in in-vitro cytoprotection assays under controlled stress conditions in preclinical cell cultures.
References
- [1]Brines M, Patel NSA, Villa P, et al. (2008). Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proceedings of the National Academy of Sciences, 105(31), 10925-10930.
- [2]Brines M, Cerami A. (2012). The innate-repair receptor as a modulator of the innate immune response. Molecular Medicine, 18(1), 486-496.
- [3]Brines M, Grasso G, Fiordaliso F, et al. (2004). Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor. Proceedings of the National Academy of Sciences, 101(41), 14907-14912.
Disclaimer: The information provided is for research reference only and does not constitute medical advice. Products are sold strictly for in-vitro research use.
Certificate of Analysis (COA)
Third-Party Verified Quality
Every batch of ARA-290is independently tested by an A2LA-accredited (ISO 17025:2017) third-party laboratory using HPLC-UV/VIS for purity and measured quantity. Each COA carries the lab's signed report and a batch-specific lot number. We publish these results publicly so you can verify exactly what you're getting.
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