≥99%
221231-10-3
1815.08 g/mol
AOD-9604
AOD-9604 is a modified C-terminal fragment of human growth hormone supplied as a lyophilized research standard for in-vitro lipolysis assays and receptor-binding studies. Not for use in any living organism.
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Third-party tested
Supplied to qualified labs and institutional buyers. Institutional use & buyer eligibility
Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C₇₈H₁₂₃N₂₁O₂₃S₂ |
| CAS Number | 221231-10-3 |
| Molar Mass | 1815.08 g/mol |
| Amino Acid Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (hGH 176-191) |
| Synonyms | hGH Fragment 176-191, Anti-Obesity Drug 9604, AOD9604, Tyr-hGH 177-191 |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and dilute acetic acid |
| Organoleptic Profile | White lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C |
| Composition | Lyophilized hGH fragment 176-191 acetate salt |
How is AOD-9604 Used in Research?
AOD-9604 is a 16-amino acid modified C-terminal fragment of human growth hormone (hGH 177-191 with an added N-terminal tyrosine), supplied as a lyophilized research standard for in-vitro lipolysis assays and receptor-binding studies. The sequence corresponds to the C-terminal lipolytic domain of hGH and is characterized in laboratory workflows as a receptor-selective reference compound distinct from full-length growth hormone.
In cell-culture systems, AOD-9604 is profiled in adipocyte lipolysis assays (glycerol-release readouts on 3T3-L1 or primary adipocyte cultures) and beta-3 adrenergic receptor-binding panels. Laboratory characterization includes receptor-selectivity profiling against IGF-1-mediated pathways to confirm the fragment's distinct binding signature. Not for use in any living organism.
Researchers use this compound as an analytical reference standard for HPLC identity and purity assays, LC-MS mass-accuracy work, and as a C-terminal hGH fragment reference in receptor-selectivity profiling across adipocyte cell-culture panels.
This product is supplied in a lyophilized form and requires reconstitution prior to laboratory handling. For research and laboratory use only. Not for human or veterinary consumption.
Areas of Study
In-Vitro Lipolysis Assays
Applied as a reference compound in glycerol-release and free-fatty-acid lipolysis assays on cultured adipocyte cell lines.
Receptor-Binding Studies
Profiled in competitive binding assays against beta-3 adrenergic receptor panels and IGF-1R reference panels for selectivity characterization.
Analytical Chemistry Reference
Used as an HPLC and LC-MS identity and purity reference standard for the 16-amino acid hGH C-terminal fragment.
Structural Characterization
Characterized by mass spectrometry and circular dichroism to confirm sequence identity and disulfide connectivity.
Receptor-Selectivity Profiling
Employed to differentiate C-terminal fragment binding patterns from full-length hGH reference ligands in cell-culture panels.
References
- [1]Ng FM, Sun J, Sharma L, et al. (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Hormone Research, 53(6), 274-278.
- [2]Heffernan MA, Thorburn AW, Fam B, et al. (2001). Characterization of fat-oxidation markers in rodent models by chronic administration of human growth hormone or a modified C-terminal fragment. International Journal of Obesity, 25(10), 1442-1449.
- [3]Kwok HH, Mok DK, Chan PH, et al. (2012). Growth hormone fragment 176-191 in articular cartilage preclinical models. Osteoarthritis and Cartilage, 20(Suppl 1), S142.
Disclaimer: The information provided is for research reference only and does not constitute medical advice. Products are sold strictly for in-vitro research use.
Certificate of Analysis (COA)
Third-Party Verified Quality
Every batch of AOD-9604is independently tested by an A2LA-accredited (ISO 17025:2017) third-party laboratory using HPLC-UV/VIS for purity and measured quantity. Each COA carries the lab's signed report and a batch-specific lot number. We publish these results publicly so you can verify exactly what you're getting.
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Frequently Bought Together
AOD-9604
5mg
$45
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Bundle total
$235