≥99%
62568-57-4
848.82 g/mol
DSIP
Delta Sleep-Inducing Peptide (DSIP). A naturally occurring nonapeptide supplied as a lyophilized reference standard for in-vitro receptor-binding and circadian-pathway assay research. Not for use in any living organism.
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Characteristics
| Property | Value |
|---|---|
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
| CAS Number | 62568-57-4 |
| Molar Mass | 848.82 g/mol |
| Amino Acid Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Synonyms | Delta Sleep-Inducing Peptide, DSIP, Emideltide |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and dilute acetic acid |
| Organoleptic Profile | White lyophilized powder; odorless |
| Purity | ≥98% by HPLC |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 7 days |
How is DSIP Used in Research?
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated from the cerebral venous blood of rabbits during electrically induced sleep by Schoenenberger and Monnier in 1977. The peptide consists of nine amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) and has been identified in various brain regions as well as peripheral tissues. DSIP is notable for its amphiphilic properties, which allow it to cross the blood-brain barrier, and for its remarkably diverse range of reported biological activities extending well beyond sleep modulation.
Research into DSIP's effects on slow-wave EEG markers has produced mixed but intriguing results. Some studies have demonstrated increases in delta (slow-wave) sleep in animal research models and research systems, while others have reported more nuanced effects on sleep-wake cycling and circadian phase adjustment in preclinical models. Beyond sleep, DSIP has been investigated for its role in stress-response modulation, with studies showing attenuation of stress-induced metabolic and endocrine markers in preclinical models. The peptide appears to modulate hypothalamic-pituitary-adrenal (HPA) axis activity and has been reported to normalize cortisol and ACTH markers under stress conditions in research models.
Additional research has explored DSIP's effects on pain-perception research readouts, with some studies suggesting analgesic-assay activity mediated through opioid receptor interactions. The peptide has also been investigated for its antioxidant-assay activity and its modulation of free-radical metabolism markers, which has generated interest in neuroprotective assay model research.
This product is supplied in a lyophilized form and requires reconstitution prior to laboratory handling. For research and laboratory use only. Not for human or veterinary consumption.
Areas of Study
Sleep Regulation
Originally isolated as a sleep-promoting factor; investigated for modulation of delta-wave (slow-wave) EEG markers in preclinical models.
Circadian Rhythm Modulation
Studied for effects on circadian phase adjustment and normalization of disrupted sleep-wake cycles.
Stress Response
Research demonstrates attenuation of stress-induced metabolic and endocrine disturbances through HPA axis modulation.
Neuroendocrine Regulation
Investigated for normalization of cortisol, ACTH, and other neuroendocrine markers under physiological and pathological stress conditions.
References
- [1]Schoenenberger GA, Monnier M. (1977). Characterization of a delta-electroencephalogram (sleep)-inducing peptide. Proceedings of the National Academy of Sciences, 74(3), 1282-1286.
- [2]Graf MV, Kastin AJ. (1984). Delta-sleep-inducing peptide (DSIP): a review. Neuroscience & Biobehavioral Reviews, 8(1), 83-93.
- [3]Prudchenko IA, Stashevskaya LV, Mikhaleva II, Ivanov VT. (1994). Delta sleep-inducing peptide: structural analogues and immunoreactive analogues. Bioorganic Chemistry, 20(10-11), 1046-1058.
- [4]Kovalzon VM, Strekalova TV. (2006). Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Journal of Neurochemistry, 97(2), 303-309.
Disclaimer: The information provided is for research reference only and does not constitute medical advice. Products are sold strictly for in-vitro research use.
Certificate of Analysis (COA)
Third-Party Verified Quality
Every batch of DSIPis independently tested by an A2LA-accredited (ISO 17025:2017) third-party laboratory using HPLC-UV/VIS for purity and measured quantity. Each COA carries the lab's signed report and a batch-specific lot number. We publish these results publicly so you can verify exactly what you're getting.
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